Angle of Hop Twine

So I found a nice sunny spot for my hops.  I’m going to plant them next to my shed and attached the twine to the shed roof.  At the apex, the height is probably 12 feet.  I want to plant 4 rhizomes ( 2 cascade & 2 Centennial ), but as I move the the slope of the roof I lose some height so I was thinking of angling out the twine to gain some back.

Is there an angle at which point they won’t grow right?  I know they can be trained horizontally but shouldn’t they go up first?

Also, how far apart should each rhizome be?  If I mount them, and try to cut the roots around the mounds as they grow, can they be within a couple feet of each other? ( Maybe I’d put a little distance between the 2 different varieties ).

Thanks.

The angle on mine is about 65 degrees.

Hops dont care about angle, they just need lots of sun, good dirt, water and a place to roam off the ground.
I think Denny has a GIANT Cascade that grows on a fence.

The first year they were at about 45-50 degrees because I let them grow up a big tomato cage and then up to the roof of the house.
Since then they have been at 65 or so